ALEC mice - Animal Life Expectancy Comparisons in Mice

Range limit to

486 cohorts selected out of 486 total, 829 median lifespan -

Strain	Sex	Treatment	Dosage	Temperature	Density	Start age	Study	Lifespan	Year	Site	Overmortality

UM-HET3	male	INT-767 FXR/TGR5 agonist	180 ppm			300 days	PMID 30688027 2019	med 900 max 1219	2012	University of Michigan at Ann Arbor	Calculate	Plot
UM-HET3	male	Acarbose	1000 ppm			480 days	PMID 27312235 2016	med 793 max 1285	2012	University of Texas Health Science Center	Calculate	Plot
UM-HET3	male	4-OH-PBN	315 ppm	21°C - 23°C	3	120 days	PMID 18631321 2009	med 713 max 1077	2004	The Jackson Laboratory	Calculate	Plot
UM-HET3	male	Control					PMID 30688027 2019	med 758 max 1260	2012	University of Texas Health Science Center	Calculate	Plot
UM-HET3	male	Aspirin	20 ppm	21°C - 23°C	3	120 days	PMID 18631321 2009	med 846 max 1201	2004	The Jackson Laboratory	Calculate	Plot
UM-HET3	male	2-(2-Hydroxyphenyl)benzoxazole	1 ppm			450 days	PMID 30688027 2019	med 741 max 1121	2012	University of Texas Health Science Center	Calculate	Plot
UM-HET3	male	Control		21°C - 23°C	3		PMID 18631321 2009	med 763 max 1216	2004	The Jackson Laboratory	Calculate	Plot
UM-HET3	male	INT-767 FXR/TGR5 agonist	180 ppm			300 days	PMID 30688027 2019	med 772 max 1061	2012	University of Texas Health Science Center	Calculate	Plot

Lifespan: what is surprising?
This project is aimed at providing the answers to questions like:

What are the longest and shortest living strains of mice?
How does temperature affect the lifespan of worms?
Which strain of rats lives the same long on different diets?
Has there been any change in the lifespan of the same fly species with the same keeping conditions over time?
Which husbandry conditions produce the longest lifespan in certain species?

References:
[1] ITP: Intervention Testing in Mice
[2] ITP in worms
[3] DrugAge
[4] Lucanic M, et al. Pharmacological lifespan extension of invertebrates. doi: 10.1016/j.arr.2012.06.006.